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专家信息 科学研究 论文专著 荣誉奖励

专家信息:


郭瑞庭,男,博士后。现任中国科学院天津工业生物技术研究所(筹)研究员、一级项目负责人,天津市特聘专家。

教育及工作经历:

2007年于台湾中央研究院国际研究生学程(Chemical Biology and Molecular Biophysics;化学生物暨分子生物物理学程)与台湾大学生化科学研究所获博士学位。

2007年于美国 The Scripps Research Institute 从事博士后研究。

2009年进入台湾基酵生物技术公司,任职研发总监。

社会任职:

1. 江南大学客座教授。

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科学研究:


研究方向:

主要从事工业酶基因的选殖、酶蛋白纯化、基因改造、酶学研究(包含热力学及动力学)、X光蛋白晶体学、膜蛋白三度空间结构之解析、工业酶及膜蛋白发酵技术探究。

承担科研项目情况:

1. 科技支撑计划项目:新型纺织酶的X光结构解析、基因改造及开发,负责人。

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科研成果:

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论文专著:


在 PNAS, JBC,Structure,JACS,JMB,Proteins 等杂志上发表 SCI 论文共20余篇。

出版专著:

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发表论文:

1. Guo, R. T., Chou, L. J., Chen, Y. C., Chen, C. Y., Pari, K, Jen, C. Y., Lo, S. C., Huang, S. L., Lee, C. Y., Chang, T. W., Chuang, W. J. (2001) Expression in Pichia pastoris and Characterization by Circular and NMR of Rhodostomin. Proteins: Structure, Function, and Genetics. 43, 499-508.

2. Guo, R. T., Ko, T. P., Chou, C. C., Shr, H. L., Chu, H. M., Tsai, Y. H., Liang, P. H., and Wang, A. H.-J. (2003) Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. Acta Crystallogr. Sect. D Biol. Crystallogr. 59, 2265-2268.

3. Guo, R. T., Kuo, C. J., Chou, C. C., Ko, T. P., Shr, H. L., Liang, P. H., and Wang, A. H.-J. (2004) Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. J. Biol. Chem. 279, 4903-4912.

4. Guo, R. T., Kuo, C. J., Ko, T. P., Chou, C. C., Liang, P. H., and Wang, A. H.-J. (2004) A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long-chain trans-prenyl products. Biochemistry. 43, 7678-7686.

5. Chu, H. M., Guo, R. T., Lin, T. W., Chou, C. C., Shr, H. L., Lai, H. L., Tang, T. Y., Cheng, K. J. Selinger, B. L., and Wang, A. H.-J. (2004) Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis. Structure. 12, 2015-2024.

6. Guo, R. T., Ko, T. P., Chen, A. P.-C. Kuo, C. J., Wang, A. H.-J., and Liang, P. H. (2005) Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate and farnesyl thiopyrophosphate: Roles of the metal ion and conserved residues in catalysis. J. Biol. Chem. 280, 20762-20774.

7. Sun, H. Y., Ko, T. P., Kuo, C. J., Guo, R. T., Chou, C. C., Liang, P. H., and Wang, A. H.-J. (2005) Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. J. Bacteriol. 187, 8137-8148.

8. Chang, T. H., Guo, R. T., Ko, T. P., Wang, A. H.-J., and Liang, P. H. (2006) Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. J. Biol. Chem. 281, 14991-15000.

9. Guo, R. T., Cao, R., Ko, T. P., Chang, T. H., Jeng, W. Y., Kuo, C. J., Chen, C. K.-M., Hudock, M. P., Zhang, Y., Song, Y., Liang, P. H., Oldfield, E., and Wang, A. H.-J. (2007) Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc. Natl. Acad. Sci. USA 104, 10022-10027.

10. Jeng, W. Y., Ko, T. P., Liu, C. I., Guo, R. T., Liu, C. L., Shr, H. L., and Wang, A. H.-J. (2008) Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis. Nucleic Acids Res. 36, 1567-77.

11. Kuo, C. J., Guo, R. T., Lu, I. L., Liu, H. G., Wu, S. Y., Ko, T. P., Wang, A. H.-J., and Liang, P. H. (2008) Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. J Biomed Biotechnol. 2008, 841312.

12. Cao, R., Chen, C. K.-M., Guo, R. T., Wang, A. H.-J., and Oldfield, E. (2008) Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. Proteins: Structure, Function, and Genetics. 73, 431-9.

13. Chen, C. K.-M., Hudock, M. P., Zhang, Y., Guo, R. T., Cao, R., No, J. H., Liang, P. H., Ko, T. P., Chang, T. H., Chang, S. C., Song Y. C., Axelson, J., Kumar, A., Wang, A. H.-J., and Oldfield, E. (2008) Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation. Journal of Medicinal Chemistry. 51, 5594-607.

14. Wu, Y.H., Ko, T.P., Guo, R.T., Hu, S.M., Chuang, L.M., Wang, A.H.-J. (2008) Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. Structure. 16, 1714-23.

15. Zhang, Y., Cao, R., Yin, F., Hudock, M., Guo, R.T., Krysiak, K., Mukherjee, S., Gao, Y.G., Robinson, H., Song, Y., No, J.H., Bergan, K., Leon, A., Cass, L., Goddard, A., Chang, T.K., Lin, F.Y., van, B.E., Papapoulos, S., Wang, A.H.-J, Kubo, T., Ochi, M., Mukkamala, D., Oldfield, E. (2009) Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation . JACS 131, 5153-62.

16. Chen, C.K.-M., Lee, G.C., Ko, T.P., Guo, R.T., Huang, L.M., Liu, H.J., Ho, Y.F., Shaw, J.F., Wang, A.H.-J. (2009) Structure of the Alkalohyperthermophilic Archaeoglobus fulgidus Lipase Contains a Unique C-Terminal Domain Essential for Long Chain Substrate Binding. Journal of Molecular Biology. 390, 672-85.

17. Guo, R.T., Chong, Y.E., Guo, M., Yang, X.L. (2009) Unique mechanism for Ap4A synthesis by human Glycyl-tRNA synthetase. J. Biol. Chem. 284, 28968-76.

18. Cheng, Y.S., Ko, T.P., Wu, T.H., Ma, Y., Huang, C.H., Lai, H.L., Wang, A.H.-J., Liu, J.R.,* and Guo, R.T.* (2011) Crystal structure and substrate-binding mechanism of cellulase 12A from Thermotoga maritima. Proteins: Structure, Function, and Bioinformatics.79, 1193-204. (featured on cover)

19. Zeng, Y.F., Ko, T.P., Lai, H.L., Cheng, Y.S., Wu, T.H., Ma, Y., Chen, C.C., Yang, C.S., Cheng, K.J., Huang, C.H., Guo, R.T.* and Liu, J.R.* (2011) Crystal structures of Bacillus alkaline phytase in complex with calcium and inositol hexasulfate. Journal of Molecular Biology 409, 214-24. (featured on cover)

20. Wu, T.H., Huang, C.H., Ko, T.P., Lai, H.L., Ma, Y., Chen, C.C., Cheng, Y.S., Liu, J.R.,* and Guo, R.T.* (2011, in press) Diverse Substrates Recognition Mechanism Revealed by Thermotoga maritima Cel5A Structures in Complex with Cellobiose and Mannotriose. BBA-Proteins and Proteomics. (featured on cover)

21. Tseng, C.W., Ko, T.P., Guo, R.T., Huang, J.W., Wang, H.C., Huang, C.H., Cheng, Y.S., Wang, A.H.-J., and Liu, J.R. (2011, in press) Substrate binding of a GH5 endoglucanase from the ruminal fungus Piromyces rhizinflata. Acta Crystallographic Section F. 67, 1189-1195. (featured on cover)

22. Huang, J.W., Cheng, Y.S., Ko, T.P., Lin, C.Y., Lai, H.L., Chen, C.C., Ma, Y., Zheng, Y., Huang, C.H., Zou, P., Liu, J.R.,* and Guo, R.T.* (2011, in press) Rational design to improve thermostability and specific activity of the truncated Fibrobacter succinogenes 1,3-1,4-β-D-glucanase. Appl Microbiol Biotechnol.

荣誉奖励:


1. 2007年获中国化学制药股份有限公司第十七届王民宁先生奖之国内医药研究所博士班优秀论文奖第一名。

2. 2007年获台大生命科学院博士毕业生院长奖第一名。

3. 2007年获台湾行政院国家科学委员会补助赴国外从事博士后研究之出国留学奖学金。

4. 2010年入选天津千人计划。

5. 2011年入选中国科学院“百人计划”。

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