科学研究:
研究方向:长期从事新型核苷的合成及其抗癌和抗病毒性质的研究。
1.核苷类化合物分子设计及其抗病毒活性研究
2.有机合成方法研究
3.储热材料及储热系统研究
承担科研项目情况:
资料更新中…………
发明公开:
[1]武钦佩,孙璐,李亚婷. 氢氧化物储热材料[P]. CN110628392A,2019-12-31.
[2]武钦佩,李林志. 氢氧化物储热材料[P]. CN110257016A,2019-09-20.
[3]武钦佩,孙璐. 中温跨季储热材料[P]. CN109777373A,2019-05-21.
[4]武钦佩,马俊展,孙璐. 一种熔盐储热材料[P]. CN108467712A,2018-08-31.
[5]武钦佩,武广龙. 由吡啶盐制备4,5-二取代1,2,3-三氮唑的方法[P]. CN108358859A,2018-08-03.
[6]武钦佩,武广龙. 4,5-二取代1,2,3-三氮唑的合成方法[P]. CN108341786A,2018-07-31.
[7]武钦佩,蒋祝平. 前列腺治疗仪[P]. CN103751006A,2014-04-30.
[8]武钦佩,吴宗友,赵华. 太阳能通风换气系统[P]. CN102889663A,2013-01-23.
[9]吴玉凯,武钦佩,陈甫雪,张存中,王雪梅,王倩,吴京. 一种电解用修饰不锈钢电极及其制备方法[P]. CN102787328A,2012-11-21.
[10]吴玉凯,陈甫雪,谢嫚,王国青,周智明,武钦佩,王倩,吴京. 一种电解用修饰活性炭电极及其制备方法[P]. CN102719847A,2012-10-10.
[11]吴玉凯,陈甫雪,武钦佩,赵之平,张衍文,唐崇新,王国青,丁春淡,祝捷,王倩,吴京. 一种电解用修饰金属钛钢电极及其制备方法[P]. CN102718289A,2012-10-10.
[12]吴玉凯,王雪梅,武钦佩,丁春淡,王国青,刘厚丽,于晓艳,侯庆伟. 一种节电的电解处理废水的方法[P]. CN102701336A,2012-10-03.
[13]武钦佩,刘海,张青山. 污泥干化设备[P]. CN102603147A,2012-07-25.
[14]武钦佩,夏江涛. 太阳能转换设备[P]. CN102494410A,2012-06-13.
[15]武钦佩,夏江涛. 提供高温液汽的太阳能转换设备[P]. CN102494411A,2012-06-13.
[16]武钦佩,夏江涛,武岳. 多功能净化设备[P]. CN102358630A,2012-02-22.
[17]武钦佩,夏江涛,夏国涛,武岳. 多功能废水和废物处理设备[P]. CN102358631A,2012-02-22.
[18]张青山,宁卓远,李云政,武钦佩,尹宏权,马东霞. 一种聚草酸-1,4-丁二醇酯的制备方法[P]. CN102219891A,2011-10-19.
[19]武钦佩,于金兰,张青山,李云政. 具有抗癌和抗病毒活性的核苷类化合物和制备方法及用途[P]. CN102120751A,2011-07-13.
[20]武钦佩,张青山,李云政,席小东. L-赤型生物喋呤的制备方法[P]. CN101792445A,2010-08-04.
[21]武钦佩,张青山,李云政,席小东. L-赤型生物喋呤的制备方法[P]. CN101792446A,2010-08-04.
[22]武钦佩. 有机废水的矿化降解方法和设备[P]. CN101654297,2010-02-24.
[23]武钦佩,张青山,李云政. 矿化降解有机废水的方法和处理设备[P]. CN101643266,2010-02-10.
[24]武钦佩,张青山,李云政. 多氯化物废物的处理方法和处理设备[P]. CN101428888,2009-05-13.
发明授权:
[1]武钦佩,孙璐. 中温跨季储热材料[P]. CN109777373B,2021-01-26.
[2]武钦佩,蒋祝平. 前列腺治疗仪[P]. CN103751006B,2016-06-08.
[3]武钦佩,吴宗友,赵华. 太阳能通风换气系统[P]. CN102889663B,2016-01-20.
[4]武钦佩,刘海,张青山. 污泥干化设备[P]. CN102603147B,2015-08-26.
[5]张青山,宁卓远,李云政,武钦佩,尹宏权,马东霞. 一种聚草酸-1,4-丁二醇酯的制备方法[P]. CN102219891B,2012-07-25.
[6]武钦佩,张青山,李云政,席小东. L-赤型生物喋呤的制备方法[P]. CN101792445B,2012-05-30.
实用新型:
[1]武钦佩,蒋祝平. 前列腺治疗仪[P]. CN203609637U,2014-05-28.
[2]武钦佩,吴宗友,赵华. 无能耗通风换气系统[P]. CN202745336U,2013-02-20.
[3]武钦佩,刘海,张青山. 污泥脱水技术设备[P]. CN202625997U,2012-12-26.
[4]武钦佩,夏江涛. 聚光换能设备[P]. CN202598900U,2012-12-12.
[5]武钦佩,夏江涛. 提供高温液汽的聚光换能设备[P]. CN202598902U,2012-12-12.
[6]武钦佩,夏江涛,夏国涛,武岳. 多功能处理设备[P]. CN202303979U,2012-07-04.
[7]武钦佩,夏江涛,武岳. 多功能环保净化设备[P]. CN202246146U,2012-05-30.
[8]武钦佩,张青山,李云政. 矿化降解有机废水的处理设备[P]. CN201354338,2009-12-02.
论文专著:
出版专著:
1. 保护基化学, 武钦佩,李善茂,化学工业出版社, 2007
本书较为详尽地介绍了常见官能团的常用保护方法,包括保护基团的性质,形成保护的方法,脱除保护的方法及有关反应机理;精选了大约700个反应,1000余篇参考文献和相关综述文献。第一章概括地介绍了常用(经典)保护基团,特征脱除保护方法和官能团保护策略等;第2~7章分别介绍了羟基、酚羟基、邻二羟基、羰基、羧基和氨基的保护和脱保护方法。本书十分适合保护基入门和提高,系统性强、重点突出。
2. MATHCAD PLUS 6.0使用及其实例, 李善茂 杜国梁 武钦佩,国防工业出版社, 1998
部分已经发表的论文:
1 Lin Zhu, Ya-Ting Li, Deng-Yu Wang, En-Xu Ren, Zhi-Bin Xu*, Qin-Pei Wu*, Superior performance of Ca(OH)2-CaO-H2O system doped with cerium and lithium for thermochemical energy storage. Catalysis Research. 2022,1(1):02 DOI: https://doi.org/10.35702/catalres.1001
2 En-Xu Ren, Deng-Yu Wang, Ya-Ting Li, Lin Zhu, Chao-Yang Chang, Lu Sun, Zhi-Bin Xu, Qin-Pei Wu, Thermochemical energy storage drastically enhanced by zirconium oxide and lithium hydroxide for magnesium hydroxide, Energy Storage, 2022,DOI: 10.1002/est2.292
111111111
3 Yikun Chen, Yongxin Gao, Yujun He, Gang Zhang, Hui Wen, Yuchen Wang, Qin-Pei Wu, Huaqing Cui , Determining Essential Requirements for Fluorophore Selection in Various Fluorescence Applications Taking Advantage of Diverse Structure–Fluorescence Information of Chromone Derivatives, Journal of Medicinal Chemistry, 2021, 64(2), 1001-1017, DOI:10.1021/acs.jmedchem.0c01508
4 Meng-Tian Li, Ya-Ting Li, Lu Sun, Zhi-Bin Xu, Yun Zhao, Zi-Hui Meng, and Qin-Pei Wu*, Tremendous enhancement of heat storage efficiency for Mg(OH)2-MgO-H2O thermochemical system with addition of Ce(NO3)3 and LiOH, Nano Energy, 2021, 81, 105603. 10.1016/j.nanoen.2020.105603
5 Zhang, Jimei; Zhao, Baochang; Chen, Shizhu; Wang, Yongchao; Zhang, Yuxuan; Wang, Yufei; Wei, Dengshuai; Zhang, Lingpu; Rong, Guanghua; Weng, Yuhua; Hao, Jifu; Li, Binglong; Hou, Xue-Qin; Kang, Xiaoxu; Zhao, Yao; Wang, Fuyi; Zhao, Yongxiang; Yu, Yingjie*; Wu, Qin-Pei*; Liang, Xing-Jie*; Xiao, Haihua* , Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy, ACS Nano, 2020, 14(11), 14831−14845. https://dx.doi.org/10.1021/acsnano.0c03781
6 Ya-Ting Li, Meng-Tian Li, Zhi-Bin Xu, Zi-Hui Meng, Qin-Pei Wu*,Dehydration kinetics
and thermodynamics of ZrO(NO3)2-doped Ca(OH)2 for chemical heat storage,Chemical Engineering Journal,2020,399, 125841;https://doi.org/10.1016/j.cej.2020.125841
1
7. Zhang, Lin-Lin; Li, Meng-Tian; Shen, Liang-Liang; Wu, Qin-Pei*, Efficient Synthesis of 5-Trifluoromethylthio-1,2,3-Triazoles: One-Pot Multicomponent Reaction from Elemental Sulfur and TMSCF3, Synthesis,2020, 52(2): 304-310. DOI:10.1055/s-0039-1690716
8. Lin-lin Zhang, Zhi-bin Xu, Qin-pei Wu* Regioselective Synthesis of Diverse Thio-, Seleno-substituted 1,2,3-Triazoles, Current Organic Chemistry, 2019, 23, 2466-2488.DOI:10.2174/1385272823666191108101604
9 Lu Sun, Qinpei Wu, Linlin Zhang, Yating Li, Mengtian Li, Ting Gao, Shasha
Guo and Dengyu Wang, Doping Magnesium Hydroxide with Ce(NO3)3 : A Promising
Candidate Thermochemical Energy Storage Materials, IOP Conf. Ser.: Earth Environ. Sci. 2019, 295, P 032068. https://doi.org/10.1088/1755-1315/295/3/032068.
10.Zhang, Lin Lin; Li, Ya Ting; Gao, Ting; Guo, Sha Sha; Yang, Bei; Meng, Zi Hui; Dai, Qi Pu; Xu, Zhi Bin*; Wu, Qin Pei* ,Efficient Synthesis of Diverse 5- Thio- or 5-Selenotriazoles: One-Pot Multicomponent Reaction from Elemental Sulfur or Selenium, Synthesis, 2019, 51(22): 4170-4182. DOI: 10.1055/s-0039-1690618
11. Yuan, Wei yuan; Chen, Xue; Liu, Ning ning; Wen, Yi ning; Yang, Bei; Andrei, Graciela; Snoeck, Robert; Xiang, Yu hong; Wu, Yong wei; Jiang, Zhen; Schols, Dominique; Zhang, Zhuo yong; Wu, Qin pei*, Synthesis, AntiVaricella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5- Disubstituted 1,2,3-(1H)-Triazoles, Medicinal Chemistry. 2019, 15(7): 801-812. DOI:10.2174/1573406414666181109095239
12. Guang-long Wu, Qin-pei Wu*, A Domino Reaction of Pyridinium Salts: Efficient Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles, ChemistrySelect. 2018, 3:5212 –5215. https://doi.org/10.1002/slct.201800669.
13. Guang-long Wu, Qin-pei Wu*, A Mild Multi-Component Reaction for Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles from Phosphonium Salts, Aldehydes and Sodium Azide, Synthesis, 2018, 50(14):2768-2774. DOI: 10.1055/s-0037-1609720; the SYNTHESIS 官方提名为优秀论文(Best Paper Award competition except Reviews and Short Reviews; more information can be found here: http://bit.ly/thieme-bpa.)
14. Guang-long Wu, Qin-pei Wu*, metal-free multicomponent reaction for synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles, Advanced Synthesis & Catalysis,2018,360,1949—1953 DOI 10.1002/adsc.201701587.
15. Yi-ning Wen, Zhi-feng Zhang, Ning-ning Liu, Graciela Andrei , Robert Snoeck, Yu-hong Xiang, Dominique Schols, Xue Chen, Zhuo-yong Zhang , Qing-shan Zhang ,Qin-pei Wu*, Synthesis and antiviral activity of 5-(benzylthio)-4-carbamyl-1,2,3-triazoles against human cytomegalovirus (CMV) and varicella-zoster virus (VZV),Med. Chem. 2017, 13(5) 453-464, DOI 10.2174/1573406413666170307165236
16. 文逸宁;袁伟媛;吴勇巍;陈雪;相玉红;张卓勇;刘宁宁; ANDREI Graciela; SNOECK Robert;
SCHOLS Dominique; 武钦佩*; 1,2,3-三氮唑类化合物的合成及抗病毒活性,中国药物化学杂
志,2016, 26,1:18-23.WEN Yi-ning, YUAN Wei-yuan, WU Yong-wei, CHEN Xue, XIANG Yuhong, ZHANG Zhuo-yong, LIU Ning-ning, ANDREI Graciela, SNOECKRobert, SCHOLS Dominique, WU Qin-pei*, Synthesis and antiviral activity of 1,2,3-triazole derivatives, Chin. J. Med. Chem. ,2016,26(01):18-23.
17. Yi-ning Wen, Zhi-feng Zhang, Ning-ning Liu, Yu-hong Xiang, Zhuo-yong Zhang, Graciela Andrei, Robert Snoeck, Dominique Schols,Qing-shan Zhang, and Qin-pei Wu*, Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides,Nucleosides, Nucleotides and Nucleic Acids, 2016, 35,3,147-160,DOI:10.1080/15257770.2015.1115523
18. 文逸宁,刘宁宁,张志峰,陈雪,袁伟媛,张青山,武钦佩*,多取代三氮唑化合物的合成
及其抗肿瘤活性研究,中国药物化学杂志,2015, 25(5): 348-354.. Synthesis and antitumor activity of multisubstituted triazole derivatives, Chin. J. Med. Chem. 2015, 25(5): 348-354.
190. 刘宁宁,陈曦,张青山,武钦佩,甲基咪唑三氟甲磺酸盐催化缩醛的合成,有机化学,2014,
34(7), 1364-1368.Liu Ningning*; Chen Xi; Zhang Qingshan; Wu Qinpei. Acetalization Catalyzed by Reusable N-Methylimidazole Trifluoromethyl Sulfonate,Chinese Journal of Organic Chemistry, 2014, 34(7), 1364-1368.
20. 刘宁宁,杜体建,杨玲,张青山,武钦佩,司他夫啶衍生物的合成及其抗肿瘤活性评价, 中国药物化学杂志,2014, 24 , 265-270.Synthesis and antitumor activity of stavudine derivatives, Chin. J. Med.Chem. 2014, 24, 265-270.
21. 刘宁宁, 杨玲, 杨蓓, 王金棒, 陈雪, 武钦佩,缩醛的直接烷基化反应,有机化学,2014,34 (12), 2523-2528.Alkylation of Indole and Benzofuran with Acetals, Chinese Journal of Organic Chemistry, 2014, 34 (12), 2523-2528.
22. 刘宁宁; 陈曦; 张青山; 武钦佩 可循环使用的N-甲基咪唑三氟甲磺酸盐催化缩醛化反应 有机化学 2014, (07): 1364-1368.
23. Liu, Ning-ning; Yu, Pan; Yuan, Wei-yuan; Zhang, Qing-shan; Wu, Qin-pei*,An Efficient and Environmentally Friendly Method for Directly Converting Trityl and Benzyl Ethers to the Corresponding Acetates,Journal of the Chinese Chemical Society, 2014, 61(9): 985-989.
24. Zhang, Xue-Lin; Yu, Pan; Wu, Yong-Wei; Wu, Qin-Pei*; Zhang, Qing-Shan,Reductive amination of acetals by anilines in the presence of triethylsilane and iodine, Journal of Chemical Research. 2014, 38(5): 261-264.
25. Zhang, Xue-Lin; Wu, Qin-Pei*; Zhang, Qing-Shan,Efficinet three-component Strecker reaction of acetals and aromatic amines catalyzed by Hafnium tetrachloride at room temperature, Journal of Chemical Research. 2013, 37(11): 690-693.
26. Zhang, Xue-Lin; Wu, Qin-Pei*; Zhang, Qing-Shan,A multicomponent reaction of acetals for the preparation of Quinolines, Journal of Chemical Research, 2013, 37(11): 677-680.
27. Zhang, Xue-Lin; Wu, Qin-Pei*; Zhang, Qing-Shan,Indium-catalyzed multicomponent reaction of acetals with dibenzylamine and alkynes, Journal of Chemical Research, 2013,37 (11): 697-700.
28. Ning, Zhuo Yuan; Zhang, Qing Shan; Wu, Qin Pei; Li, Yun Zheng; Ma, Dong Xia; (Chen, Jia Zhe, Efficient synthesis of hydroxyl functioned polyesters from natural polyols and sebacic acid , Chinese Chemical Letters. 2011,: 22( 6), 635-638 DOI: 10.1016/j.cclet.2010.12.033
29. Ti-Jian Du, Qin-Pei Wu, * Hai-Xia Liu, Xi Chen, Yi-Nan Shu, Xiao-Dong Xi, Qing-Shan Zhang, Yun-Zheng Li , An Atom-Efficient And Powerful Method For Direct Esterification Of Silyl Ethers Catalyzed By HClO4–SiO2, Tetrahedron, 2011, 67(6): 1096-1101.
30. Yu, Jinlan; Zhang, Qingshan; Liu, Yanhong; Li, Yunzheng; Wu, Qinpei.(5S*,6R*,7R*)-6-Formyl-5-phenyl-7-propylperhydropyrazolo[1,2-a]pyrazol-1 -one.Acta Crystallographica Section E-Structure Reports Online, 2010, 66.
31. Jin-Lan Yu, Qin-Pei Wu*, Qing-Shan Zhang, Xiao-Dong Xi, Ning-Ning Liu, Zheng-Yun Li, Yan-Hong Liu, Hong-Quan Yin, Synthesis and Antitumor Activity of Novel 2',3'-Diethanethio-2',3',5'-trideoxy-5'-triazolonucleoside Analogues,European Journal of Medicinal Chemistry, 2010, 45(7): 3219-3222.
32. Yu, Jin-Lan; Wu, Qin-Pei*; Zhang, Qing-Shan; Liu, Yan-Hong; Li, Yun-Zheng; Zhou, Zi-Ming., Synthesis and antitumour activity of novel2',3'-dideoxy-2',3'-diethanethionucleosides bearing 1,2,3-triazole residues, Bioorganic & Medicinal Chemistry Letters. 2010, 20(1): 240-243.
33. Wu Qin-Pei*, Liu Hua, Liu Hai-Xia, Chen Xi, Wang Hao, Zhang Qing-Shan and Li Yun-Zheng, Practical and Efficient Acylation and Tosylation of Sterically Hindered Alcohols Catalyzed with 1-Methylimidazole. Chemistry Research in Chinese University, 2010, 26(1): 55-59.
34. 于金兰; 武钦佩; 张青山; 周智明 1,4-二取代-1,2,3-三唑衍生物的合成 合成化学 ,2010,18(01):56-60.
35. Liu, Hai-Xia; Wu, Qin-Pei*; Shu, Yi-Nan; Chen, Xi; Xi, Xiao-Dong; Du, Ti-Jian; Zhang, Qing-Shan, A mild, efficient and selective procedure for direct transprotection of acetonides to acetates catalyzed with HClO4-SiO2,Carbohydrate Research, 2009, 344(17): 2342-2348.
36. Qin-Pei Wu*, Xiao-Dong Xi, Xi Chen, Hui Li, Qing-Shan Zhang Yun-Zheng Li, A Vicinal Acyloxy Group Participation SN2 Reaction of Thiol nucleophiles in the Formation of Thioacetals, Chinese Journal of Chemistry, 2009, 27(10): 1962-1966.
37. Xiao-Dong Xi, Da-Xin Shi, Hui Li, Yun-Zheng Li, Qin-Pei Wu*, 4,5,6-Tri-O-acetyl-2,3-di-S-ethyl-2,3-dithio -D-allose diethyl dithioacetal, Acta Cryst. 2009, E65, o1227.
38. Wu, Qin-Pei; Shi, Da-Xin; Wang, Hao; Zhang, Qing-Shan。(R)-2-[(R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-1,3-oxathiolan-5-one.Acta Crystallographica Section E-Structure Reports Online, 2009, 65: 1483.
39. Qinpei Wu*, MingXin Zhou, XiaoDong Xi, Di Song, Yuan Wang, Yun Zheng Li and QingShan Zhang, A Facile One-pot Procedure for Transformation of Acetonides into Diacetates Catalyzed with Bi(OTf)3 center dot xH2O,Tetrahedron Letters, 2008, 49(17): 2714-2718.
40. Qinpei Wu*, Yuan Wang, Hua Liu, Yunbo Qu, Qingshan Zhang, Mild, efficient and highly selective hydrolysis of acetonides with antimony trichloride, Letters in Organic Chemistry,. 2006, 271-274.
41. Qinpei Wu*, Wei Chen, Yuan Wang, Hao Wang, Efficient and selective cleavage of silyl ethers with antimony trichloride, Letters in Organic Chemistry, 2006, 3(1): 13-15.
42. Qinpei Wu*, Wei Chen, Yuan Wang, Hua Liu, Mild, efficient, and selective cleavage of trityl ethers with antimony trichloride, Synthetic Communications, 2006, 36(10): 1361-1366..
43. 王浩; 武钦佩 核苷类抗病毒化合物的研究进展 生命科学仪器 ,2006,(01):11-14.
44. C. Simons, Qinpei Wu* and T. T. Htar, Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics, Current Topics in Medicinal Chemistry, 2005, 5(13): 1191-1203..
45. Wu Q. P.*; Simons, C.*. Synthetic Methodologies for C-nucleosides, Synthesis, 2004, 1533-1555.
46. Reese C. B. and Wu, Q. P. Conversion of 2-Deoxy-D-ribose into 2-Amino-5-(2-deoxy-beta-D- ribofuranosyl)-pyridine, 2’-Deoxypseudouridine and Other C-(2’-deoxyribonucleosides), Org. Biomol. Chem., 2003, 1(18), 3160-3172.
47. 朱湛; 武钦佩; 张青山; 郭炳南; 王伯羲 几种二茂铁衍生物对硝胺推进剂的催化燃烧作用 兵工学报,1996(02):119-122.
会议论文:
1. Yang Bei*; Wen Yi ning; Jiang Zhen; Zhang Lin lin; Yu Pan; Liu Ning ning; Zhang Jian; Wu Qin pei.One-Pot Reaction for Synthesis of 1,2,3-Triazole Thioethers from Iodotriazole, Sulfur and Alkylhalides/Tosylates.International Symposium on Energy Science and Chemical Engineering (ISESCE), 2015-12-12 to 2015-12-13.
2. Wu Q; Huang B*; Wang G Y; Wang J D.Numerical investigation of the hydroelastic response in cavitating flow around a flexible hydrofoil.International Symposium on Cavitation and Multiphase Flow (ISCM), 2014-10-18 to 2014-10-21.
3. 武钦佩,席小东,张青山. 邻基参与的缩硫醛反应[C].中国化学会第26届学术年会有机化学分会场论文集.2008:178.
4. 武钦佩,王媛,张青山,郭炳南. 丙酮化物与二乙酸酯的一步转化法[C].中国化学会第二十五届学术年会论文摘要集(上册).2006:563.