陈强——药学专家

科学研究：

研究方向：

长期从事生物传感器相关领域的研究与教学工作，在生物传感器、包合物化学、生物电化学等方面有较深入的研究，创新性地将所设计的新型生物传感技术应用于活血化瘀中药有效成分作用机理研究，初步建立了一种可用于中药有效成分作用机理研究的新方法。

承担的科研项目情况：

主持、分担了国家自然科学基金、“863”计划、教育部、天津市、日本文部省及著名企业财团等科研开发项目20余项。

科研成果：

1 养殖水生态环境修复微生态菌制剂的研究与开发张清敏;王兰;胡国臣;朱琳;钟欢;侯树宇;余海晨;陈强;陈旭;任富海南开大学 2004

2 用于生物传感器的高性能纳米级结构酶电极技术研究陈强;史海滨;吴宝艳;许鑫华;黄加栋;李静;韩君;杨钰;宋昭;赵紫霞南开大学 2005

3 生物酶单分子定向排列累积膜高效生物传感器及乳酸、血糖快速检测开发研究陈强;刘安西;刘燕强;赵强;贺秉军;孙金生南开大学 2002

4 高性能纳米水平光、电化学生物传感器的开发陈强;许鑫华;赵强;贺秉军;韩君;史海滨;吴宝艳;付英松南开大学 2003

5 特异选择性生物传感技术对活血化淤中药作用机理的研究陈强;许鑫华;李静;缪宇;马春涛;韩君;史海滨;吴宝艳;黄亮;刘东波南开大学 2005

发明专利：

1 一种多功能血液检测芯片郝鹏飞; 姚朝晖; 陈强; 史海滨清华大学; 南开大学 2003-12-10

2 生物传感器用的生物酶电极及其制备方法陈强; 吴宝艳; 韩君; 黄加栋; 史海滨; 韩松岩; 蒋琳洁南开大学 2005-01-12

3 修复养殖水环境的微生态菌制剂及其制备方法张清敏; 王兰; 胡国臣; 侯树宇; 余海晨; 陈强; 陈旭; 任富海; 朱琳; 钟欢南开大学 2005-03-16

4 测定中药作用机理的方法陈强; 陈可冀; 李静; 殷惠军; 吴宝艳; 黄加栋; 韩松岩; 史海滨南开大学 2005-03-23

5 中药作用机理的测定方法陈强; 陈可冀; 吴宝艳; 殷惠军; 黄加栋; 李静; 史海滨南开大学 2005-03-23

6 用于生物传感器的酶电极陈强; 吴宝艳; 李明智; 王淑芳; 史海滨; 谢伟; 韩松岩; 黄亮; 刘东波南开大学; 天津南开戈德集团有限公司 2004-12-01

7 生物传感器用的生物酶电极陈强; 李明智; 吴宝艳; 王淑芳; 史海滨; 谢伟; 韩松岩; 黄亮; 刘东波; 蒋琳洁天津南开戈德集团有限公司; 南开大学 2004-12-08

8 用于残留农药检测的酶电极陈强; 宋昭; 黄加栋; 吴宝艳; 史海滨; 李二虎; 贺秉军; 吕宪禹南开大学 2005-09-07

资料更新中……

论文专著：

在国内外核心刊物发表论文80余篇，其中40余篇被SCI、EI收录。

发表论文：

英文：

1. Zixia Zhao, Mingqiang Qiao, Feng Yin, Bin Shao, Baoyan Wu, Yanyan Wang, Xinsheng Wang, Xia Qin, Sha Li, Lei Yu, Qiang Chen. Amperometric glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization. Biosensors & Bioelectronics, 2007,22:3021-3027 (SCI, IF 5.061)

2. Baoyan Wu, Shihua Hou，Feng Yin, Zixia Zhao, Yanyan Wang, Xinsheng Wang, Qiang Chen. Amperometric glucose biosensor based on multilayer films via layer-by-layer self-assembly of multi-wall carbon nanotubes, gold nanoparticles and glucose oxidase on the Pt electrode. Biosensors &Bioelectronics,2007,22:2854-2860 (SCI, IF 5.061)

3. Baoyan Wu, Shihua Hou, Feng Yin, Jing Li, Zixia Zhao, Jiadong Huang, Qiang Chen. Amperometric Glucose Biosensor Based on Layer-by-layer Assembly of Multilayer Films Composed of Chitosan, Gold Nanoparticals and Glucose Oxidase Modefied Pt Electrode. Biosensors &Bioelectronics,2007,22:838-844 (SCI, IF 5.061)

4. Haibin Shi, Yu Yang, Jiadong Huang, Zixia Zhao, Xinhua Xu, Jun-ichi Anzai, Tetsuo Osa, Qiang Chen. Amperometric Choline Biosensors Prepared by Layer-by-layer Deposition of Choline Oxidase on the Prussian Blue-Modified Platinum Electrode. Talanta,2006,70:852-858(SCI, IF 3.374)

5. WU Bao-Yan, LI Jing, HUANG Jia-Dong, Wang Yanyan, Yin Huijun, Chen Keji, CHEN Qiang. Real time kinetic analysis of the interaction between interleukin-1α and soluble interleukin-1 receptor using a resonant mirror biosensor. Analytica Chimica Acta, 2006, 557: 106-110(SCI, IF 3.186)

6. 韩松岩, 刘东波, 黄亮, 王深琪, 刘清平, 陈强. Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using qua. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 26-6-1166. 2005-1-1

7. 李静,黄加栋,吴宝艳,陈强. Effects of propyl gallate on interaction between TNF-alpha and sTNFR-I using an affinity biosensor. ACTA PHARMACOLOGICA SINICA 26-10-1212. 2005-1-1

8. 史海滨，赵紫霞,宋昭,黄加栋,杨钰,陈强. Fabricating of acetylcholine biosensor by a layer-by-layer deposition technique for determining trichlorfon. ELECTROANALYSIS 17-14-1285. 2005-1-1

9. 陈强, 韩君, 史海滨,吴宝艳, 许鑫华. Use of Chitosan for developing layer-by-layer multilayer thin films containing glucose oxidase for biosensor applications. Sensor Letters v 2-n 2-p 102-105. 2005-1-1

10. 史海滨, 宋昭, 黄加栋,杨钰,赵紫霞, 陈强. Effects of the type of polycation in the coating films prepared by a layer-by-layer deposition technique on the properties of amperometric choline sensors. Sensors and Actuators, B: Chemical v 109-n 2-p 341-347. 2005-1-1

11. 史海滨, 宋昭, 黄加栋,杨钰,赵紫霞, 陈强. Effects of the type of polycation on the amperometric response of choline biosensors prepared by a layer-by-layer deposition technique. Materials Science and Engineering C v 25-n 4-p 433-435. 2005-1-1

12. 吴宝艳, 许鑫华, 史海滨, 韩松岩,宋岩、黄亮, 陈强. Effect of cellulose acetate diffusion restricting membrane on the glucose biosensor. Tianjin Daxue Xuebao (Ziran Kexue yu Gongcheng Jishu Ban)/Journal of Tianjin University Science and Technology v 38-n 6-p 513-517. 2005-1-1

13. 尹峰;赵紫霞; 吴宝艳;王新胜; 王艳艳;陈强. Glucose biosensor based on layer-by-layer assembly of multi-walled carbon nanotubes and polyallylamine. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 35-7-1021-1024. 2007-1-1

14. 刘强; 许鑫华;张春怀; 陈强. Electrochemical deposition of composite films composed of polyaniline and chitosan for biosensor applications. SENSOR LETTERS 5-2-459-462. 2007-1-1

15. 赵紫霞; 乔明强; 尹峰; 邵兵; 吴宝艳; 王艳艳; 王新胜; 秦霞; 李莎; 于雷; 陈强. Amperometric glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization. BIOSENSORS & BIOELECTRONICS 22-12-3021-3027. 2007-1-1

16. 吴宝艳;侯识华; 尹峰; 赵紫霞; 王艳艳; 王新胜; 陈强. Amperometric glucose biosensor based on multilayer films via layer-by-layer self-assembly of multi-wall carbon nanotubes, gold nanoparticles and glucose oxidase on the Pt electrode. BIOSENSORS & BIOELECTRONICS 22-12-2854-2860. 2007-1-1

17. 刘东波; 贺秉军;韩松岩; 王申奇; 刘清平; Jun-ichi, A; Osa, T; 陈强. An adsorption behavior of low-density lipoprotein onto cholesterol-modified dextran studied by a quartz crystal microbalance. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 27-4-665-669. 2007-1-1

18. 黄加栋; 宋昭; 李静; 杨钰; 史海滨; 吴宝艳; Anzai, JI; Osa, T; 陈强. A highly-sensitive L-lactate blosensor based on sol-gel film combined with multi-walled carbon nanotubes (MWCNTs) modified electrode. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 27-1-29-34. 2007-1-1

19. 吴宝艳; 侯识华; 尹峰; 李静; 赵紫霞; 黄加栋; 陈强. Amperometric glucose biosensor based on layer-by-layer assembly of multilayer films composed of chitosan, gold nanoparticles and glucose oxidase modified Pt electrode. BIOSENSORS & BIOELECTRONICS 22-6-838-844. 2007-1-1

20. 宋昭; 黄加栋; 史海滨; 吴宝艳; 赵紫霞;陈强. Highly sensitive choline biosensor based on nanotube modified pt electrode combined with sol-gel immobilization. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 34-7-910-914. 2007-1-1

21. Li, J; Huang, JD; Wu, BY; Song, Z; Chen, Q. Optical biosensor analysis in studying propyl gallate binding to endothelin-1. SENSOR LETTERS 3-4-296. 2006-1-1

22. Chen, Q; Huang, JD; Yin, HJ; Chen, KJ; Osa, T. The applications of affinity biosensors: IAsys biosensor and quartz crystal microbalance to the study on interaction between Paeoniae radix 801 and endothelin-1. SENSORS AND ACTUATORS B-CHEMICAL 115-1-116. 2006-1-1

23. Huang, JD; Yang, Y; Shi, HB; Song, Z; Zhao, ZX; Anzai, J; Osa, T; Chen, Q. Multi-walled carbon nanotubes-based glucose biosensor prepared by a layer-by-layer technique. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 26-1-113. 2006-1-1

24. Song, Z; Huang, JD; Wu, BY; Shi, HB; Anzai, JI; Chen, Q. Amperometric aqueous sol-gel biosensor for low-potential stable choline detection at multi-wall carbon nanotube modified platinum electrode. SENSORS AND ACTUATORS B-CHEMICAL 115-2-626. 2006-1-1

25. Shi, H; Yang, Y; Huang, JD; Zhao, ZX; Xu, XH; Anzai, J; Osa, T; Chen, Q. Amperometric choline biosensors prepared by layer-by-layer deposition of choline oxidase on the Prussian blue-modified platinum electrode. TALANTA 70-4-852. 2006-1-1

26. Wu, BY; Wang, YY; Li, J; Song, Z; Huang, JD; Wang, XS; Chen, Q. An optical biosensor for kinetic analysis of soluble Interleukin-1 receptor I binding to immobilized Interleukin-1 alpha. TALANTA 70-3-485. 2006-1-1

27. Xu, XH; Ren, GL; Cheng, J; Liu, Q; Li, DG; Chen, Q. Layer by layer self-assembly immobilization of glucose oxidase onto chitosan-graft-polyaniline polymers. JOURNAL OF MATERIALS SCIENCE 41-10-3147. 2006-1-1

28. Wu, Bao-Yan; Li, Jing; Huang, Jia-Dong; Wang, Yan-Yan; Yin, Hui-Jun; Chen, Ke-Ji; Chen, Qiang. Real time kinetic analysis of the interaction between interleukin-1α and soluble interleukin-1 receptor I using a resonant mirror biosensor. Analytica Chimica Acta v 557-n 1-2-p 106-110. 2006-1-1

29. Wu, Baoyan; Li, Jing; Shi, Haibin; Huang, Jiadong; Anzai, Junichi; Osa, Tetsuo; Chen, Qiang. Ferrocene-mediated anti-interfering glucose biosensor based on glutin and cellulose acetate. High Technology Letters v 12-n 3-p 263-266. 2006-1-1

30. Yanyan Wang, Xinsheng Wang, Baoyan Wu, Zixia Zhao, Feng Yin, Sha Li, Xia Qin, Qiang Chen. Dispersion of single-walled carbon nanotubes in poly(diallyldimethylammonium chloride) for prepara. Sensors and Actuators B 130-2-809-815. 2008-3-28

31. Bao-Yan Wu, Shi-Hua Hou, Liang Huang, Feng Yin, Zi-Xia Zhao, Jun-Ichi Anzai, Qiang Chen. Oriented immobilization of immunoglobulin G onto the cuvette surface of the resonant mirror biosenso. Materials Science and Engineering C 28-7-1065-1069. 2008-8-1

32. Jiadong Huang, Jing Li, Yu Yang, Xinsheng Wang, Baoyan Wu, Qiang Chen. Development of an amperometric L-lactate biosensor based on L-lactate oxidase immobilized through silica sol-gel film on multi-walled carbon nanotubes/platinum nanoparticle modified glassy carbon electrode. Materials Science and Engineering C 28-7-1070-1075. 2008-8-1

33. Bao-Yan Wu, Shi-Hua Hou, Min Yu, Xia Qin, Sha Li, Qiang Chen. Layer-by-layer assemblies of chitosan/multi-wall carbon nanotubes and glucose oxidase for amperometric glucose biosensor applications. Materials Science and Engineering C 29-1-346-349. 2009-1-1

34. Xia Qin, Huicai Wang, Xinsheng Wang, Sha Li, Zhiying Miao, Nan Huang, Qiang Chen. Amperometric choline biosensors based on multi-wall carbon nanotubes and layer-by-layer assembly of multilayer films composed of Poly(diallyldimethylammonium chloride) and choline oxidase. Materials Science and Engineering: C 29-4-1453-1457. 2009-5-5

35. Zi-Xia Zhao, Hui-CaiWang, Xia Qin, Xin-ShengWang, Ming-Qiang Qiao, Jun-ichi Anzaib, Qiang Chen. Self-assembled film of hydrophobins on gold surface and its application to electrochemical biosensing. Colloids and Surfaces B: Biointerfaces 71-1-102-106. 2009-6-1

36. Wei Zhao, Huicai Wang, Xia Qin, Xinsheng Wang, Zixia Zhao, Zhiying Miao, Lili Chen, Miaomiao Shan, Yuxin Fang, Qiang Chen. A novel nonenzymatic hydrogen peroxide sensor based on multi-wall carbon nanotube/silver nanoparticle nanohybrids modified gold electrode. Talanta 80-2-1029-1033. 2009-12-15

37. HuicaiWang, XinshengWang, Xiaoqing Zhang, Xia Qin, Zixia Zhao, Zhiying Miao, Nan Huang, Qiang Chen. A novel glucose biosensor based on the immobilization of glucose oxidase onto gold nanoparticles-modified Pb nanowires. Biosensors and Bioelectronics 25-1-142-146. 2009-9-15

38. Sha Li, Yanyan Wang, Zixia Zhao, Xia Qin, Xinsheng Wang, Min Yu, Zhiying Miao, Baoyan Wu, Qiang Chen. Amperometric Ethanol Biosensor Based on Layer-by-Layer Deposition of Alcohol Oxidase on the Platinum. Sensor letters 6-2-347-351. 2008-4-1

39. Xia Qin, Huicai Wang, Xinsheng Wang, Zhiying Miao, Lili Chen, Wei Zhao, Miaomiao Shan, Qiang Chen. Amperometric biosensors based on gold nanoparticles-decorated multiwalled carbon nanotubes poly(dial. Sensors and Actuators B 147- 2- 593-598. 2010-6-3

40. Zixia Zhao, Qiang Chen, Jun-ichi ANZAI. Horseradish peroxidase microcapsules based on layer-by-layer polyelectrolyte deposition. Journal of Environmental Sciences 21- supplement 1- s135-s138. 2009-4-21

41. Yanyan Wang, Qiang Chen, Xiangqun Zeng. Potentiometric biosensor for studying hydroquinone cytotoxicity in vitro. Biosensors and Bioelectronics 25- 6- 1356-1362. 2010-2-15

中文：

1 层层自组装技术制备PDDA-多壁碳纳米管-胆碱生物传感器陈丽丽; 王会才; 秦霞; 王新胜; 赵紫霞; 苗智颖; 赵薇; 单苗苗; 陈强分析化学 2010-03-15

2 层层累积技术制备基于纳米碳管的葡萄糖生物传感器杨钰; 史海滨; 吴宝艳; 李静; 安顺一; 陈强传感器与微系统 2006-01-20

3 亲和型生物传感器对TNF-α/sTNFR-I相互作用的研究李静; 吴宝艳; 黄加栋; 史海滨; 陈强传感器与微系统 2006-03-20

4 白细胞介素-1α与其Ⅰ型可溶性受体的相互作用及动力学特征吴宝艳; 黄加栋; 李静; 宋昭; 王艳艳; 王新胜; 陈强分析化学 2006-06-30

5 纳米碳管修饰铂结合溶胶-凝胶固定酶制备高性能胆碱生物传感器宋昭; 黄加栋; 史海滨; 吴宝艳; 赵紫霞; 陈强分析化学 2006-07-30

6 当前中国土地价格形成的规律性探讨徐大佑; 陈强贵州财经学院学报 2007-03-15

7 基于多壁碳纳米管和聚丙烯胺层层自组装的葡萄糖生物传感器尹峰; 赵紫霞; 吴宝艳; 王新胜; 王艳艳; 陈强分析化学 2007-07-15

8 纳米银/半胱氨酸修饰葡萄糖生物传感器的研究于敏; 王会才; 秦霞; 王新胜; 吴宝艳; 陈强传感器与微系统 2008-10-20

9 基于纳米材料、聚电解质制备高性能乙醇生物传感器李莎; 王艳艳; 赵紫霞; 秦霞; 王新胜; 吴宝艳; 陈强分析化学 2008-02-15

10 层层自组装制备基于多壁碳纳米管的胆碱生物传感器秦霞; 王艳艳; 赵紫霞; 王新胜; 李莎; 于敏; 黄楠; 苗智颖; 陈强分析化学 2008-06-15

11 聚合物荧光型纳米微粒传感器的研究进展许鑫华; 傅英松; 陈强; 姚康德化学通报 2003-12-18

12 光学活性拟除虫菊酯对棉铃虫神经细胞钠通道电流的影响贺秉军; 刘东波; 陈强; 刘安西; 汪清民; 黄润秋; 芮昌辉昆虫学报 2003-04-15

13 荧光标记法检测活细胞内游离钙离子浓度的改进许鑫华; 傅英松; 韩波; 何淑兰; 王遵; 陈强科技通报 2003-08-25

14 石英晶体微天平实时监测低密度脂蛋白在胆固醇修饰葡聚糖上的吸附及其动力学研究韩松岩; 刘东波; 黄亮; 王深琪; 刘清平; 安齐顺一; 长哲郎; 陈强高等学校化学学报 2005-06-15

15 醋酸纤维素扩散限制膜修饰葡萄糖生物传感器吴宝艳; 许鑫华; 史海滨; 韩松岩; 黄亮; 陈强天津大学学报 2005-06-25

16 血瘀证基础研究的若干思考蒋跃绒; 殷惠军; 刘颖; 陈强; 陈可冀中国中医基础医学杂志 2005-08-28

17 汞电极表面痕量DNA的电化学响应及其检测(英文) 韩君; 史海滨; 安■顺一; 陈强南开大学学报(自然科学版) 2005-06-20

18 纳米金与二茂铁在葡萄糖传感器中的相互作用吴宝艳; 王艳艳; 杨钰; 宋昭; 尹峰; 陈强传感器技术 2005-10-20

19 石英晶体微天平实时监测亲和素对低密度脂蛋白的吸附刘东波; 贺秉军; 史海滨; 吴宝艳; 陈强传感器技术 2005-12-20

20 二氧化氯防治地热水黏泥的研究张清敏; 胡国臣; 陈强; 赵恩贵; 张喜成工业水处理 2003-08-25

21 高性能纳米水平光、电化学生物传感器的开发及其在中药作用机制中的应用展望陈强; 韩君; 吴宝艳天津中医药 2003-08-12

22 覆盆子等8味中药的抗超氧阴离子自由基作用研究周晔; 李一峻; 陈强; 何锡文; 李佩孚时珍国医国药 2004-02-20

23 表面等离子体共振传感技术在高分子研究中的应用许鑫华; 韩明川; 陈强; 李冬光; 姚康德高分子通报 2004-04-30

24 应用压电石英晶体生物传感器研究赤芍801与ET-1间的相互作用李静; 吴宝艳; 蒋跃绒; 殷惠军; 黄加栋; 陈可冀; 陈强中国中西医结合杂志 2004-08-20

25 亲和型生物传感器及其在中药作用机理研究中的应用展望陈强; 李静; 殷惠军; 黄加栋; 吴宝艳; 蒋跃绒; 陈可冀中国中西医结合杂志 2004-08-20

26 邻苯二甲酸二异辛酯(DEHP)对土壤中微生物和动物的影响陈强; 孙红文; 王兵; 胡国臣农业环境科学学报 2004-12-20

27 特异选择性胆固醇生物传感器的研究吴宝艳; 黄加栋; 史海滨; 刘东波; 陈强传感器技术 2005-01-20

28 体外培养法观察铅对未成年小鼠造血干/祖细胞生长的影响杨昆; 杨婧; 凌翎; 陈强; 范洪学中国妇幼保健 2006-01-30

29 铅对未成年小鼠骨髓干/祖细胞和外周血的毒性作用杨昆; 杨婧; 陈强; 凌翎; 范洪学中国妇幼保健 2006-02-28

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