1、Selection of chemical drugs as inhibitor of citrus exocortis viroid (M. Sci., 1985-1988)
2、Cloning and expression of human growth hormone releasing factor gene (supported by the key project Chinese Academy of Sciences, 1988-1990)
3、Biochemical analysis of citrus exocortis viroid (supported by the Chinese National Eighth 5-year Plan, key project, 1990-1994) with Prof. Dr. Daming Ding
4、RNA transcription aspect of viroid replication (Ph. D and Postdoc fellow, Funds of Chemistry Industry, Düsseldorf, 1996-2000) with Prof. Dr. Detlev Riesner
5、In vitro selection of duck Hepatitis B virus epsilon variants with higher affinity for P protein (Postdoc work, German Research Foundation, Freiburg, 2000-2003) with Prof. Dr. Michael Nassal
6、Mechanism of liver fibrosis (Senior Scientist, German Research Foundation and EU project, Regensburg, 2003-2005) with Prof. Dr. Jürgen Schoemerich and Dr. Bernd Schnabl
7、Developmental biology of kidneys (C1 Professor, German Research Foundation, Regensburg, 2006-2008) with Prof. Dr. Will Minuth
8、Study of the replication of hepatitis B virus (Research Professor, Chinese Academy of Sciences, key project, 2008-2011)
9、Establishment of in vitro cellular model susceptible to HBV infection (Research Professor, National 11th five-year Plan Major Science and Technology Special Project in the Field of Infectious Diseases, 2009-2011)
10、Optimization and application of in vitro cellular model susceptible to HBV infection (Research Professor, National 12th five-year Plan Major Science and Technology Special Project in the Field of Infectious Diseases, 2011-2015)
11、Screening of anti-HBV drugs and application of 3DCC in the field of regenerative medicine (Professor, Initial Project of Hubei University of Technology, 2014-2015)
主持的科研项目：
1、Underlying mechanism of liver fibrosis (Senior Scientist, German Research Foundation and EU project, Regensburg, 欧盟联合课题，2003-2005) 。
2、Tissue engineering and regeneration medicine of kidney(C1 Professor, German Research Foundation, Regensburg, 德国自然科学基金, 欧盟联合课题，2006-2008)。
3、Application of perfusion 3D cell culture technique in virology (PI, EU Project III. UNOCFG3，2008.03-2012.06) 。
[111]Yanhong Wei, Huihui Liu, Da Hu, Qun He, Chenguang Yao, Hanluo Li, Kanghong Hu,*,Jun Wangb,*.Recent Advances in Enterovirus A71 Infection and Antiviral Agents.Lab Invest 104 (2024) 100298. https://doi.org/10.1016/j.labinv.2023.100298 PDF
[110]Qian Peng , Jialu Qiao , Weiling Li , Qiang You , Song Hu , Yuchen Liu , Wei Liu , Kanghong Hu* , Binlian Sun .Global m6A methylation and gene expression patterns in human microglial HMC3 cells infected with HIV-1.Heliyon . 2023 Oct 26;9(11):e21307. https://doi: 10.1016/j.heliyon.2023.e21307. eCollection 2023 Nov.PDF
[109]Yanhong Wei, Huihui Liu, Da Hu, Qun He, Chenguang Yao, Hanluo Li, Kanghong Hu*, Jun Wang.Recent Advances in Enterovirus A71 Infection and Antiviral Agents.Lab Invest. 2023 Nov 25;104(2):100298. https://doi: 10.1016/j.labinv.2023.100298.
[108]Kanghong Hu et al. 2023 “EV-A71 mechanism of entry: receptors/co-receptors, related pathways and inhibitors “ Viruses 15,785. https://doi.org/10.3390/v15030785
[107]Kanghong Hu et al. 2023 “Legume-derived bioactive peptides in type 2 diabetes: opportunities and challenges“ Nutrients 15,1096. doi.org/10.3390/nu15051096
[106]Rominah Onintsoa Diarimalala, Yanhong Wei, Da Hu and Kanghong Hu* 2023 “Inflammasomes during SARS-CoV-2 infection and development of their corresponding inhibitors” Front. Cell. Infect. Microbiol. 13:1218039. https://doi.org/10.3389/fcimb.2023.1218039
[105]Jingsong Cui , Haiping Wang, Fang Yang, Qian Peng, Weiling Li, Kanghong Hu*, Binlian Sun* 2023 “PCN224 mediated sono-photodynamic therapy triggers apoptosis through multisite damage in hepa1-6 Cells” J. Biol. Regul. Homeost. Agents. 37(4): 1819-1828 https://doi.org/10.23812/j.biol.regul.homeost.agents.20233704.181
[104]Yanhong Wei, Da Hu, Dong Li, Kanghong Hu et al. 2023 “ Antiviral effects and mechanisms against EV71 of the novel 2-benzoxyl-phenylpyridine derivatives“ Eur J Pharm Sci 186:106445. doi:10.1016/j.ejps.2023.106445.
[95]Chen Z, Wang Y, Wang X, Xiao Z, Wu P*,Hu K* 2022 “Rational design and synthesis of organic-inorganic hexavanadate hybrids with p-halogenated benzoyl ligands” Journal of Molecular Structure 131451
[94]Wang LS*, Guo C, Hu D, Zhao YX, Liu HH, Dong YJ, Sun SB, Liu X, Hu KH & Wei YH* 2022“Syntheses, characterization andinhibition activities against coxsackievirus B3 of lodobenzoic hydrazide functionalized hexamolybdates” Frontiers in Chemistrydoi:10.3389/fchem.2022.841151
[93]Qinglin Ding, Hanluo Li, Zhigao Xu, Kanghong Hu* and Qifa Ye* 2022 “Identification of CFHR4 associated with poor prognosis of hepatocellular carcinoma” Front. Oncol. 12:812663 doi: 10.3389/fonc.2022.812663
[91]Zhen WT, Li HL, Hu KH et al. 2021 “Chondromalacia patellae:current option and emerging cell therapies” Stem Cell Research & Therapy 12:412 doi.org/10.1186/s13287-021-02478-4
[90]Zhang RJ, Bao J, Qiao JL, Li WS, Feng Q, Hu KH * and Sun BL* 2021 “Long-term efavirenz exposure induced neuroinflammation and cognitive deficits in C57BL/6 mice” Biochemical and Biophysical Research Communication584:46-52
[86]Wei Yanhong, Wang Haijie, Xi Caili, Li Ni, Li Dong, Yao Chengguang, Sun Ge, Ge Hongmei, Hu Kanghong* and Zhang Qian* 2020 “Antiviral effects of novel 2-benzoxyl-phenylpyridine derivatives”. Molecules, 2020, 25(6): 1409.;doi:10.3390/molecules25061409
[85]Rominah OD, Hu M, Wei Y, Hu KH* 2020 “Recent advances of enterovirus 71 3Cpro targeting inhibitors” Virology Journal 17:173 doi.org/10.1186/s12985-020-01430-x
[84]Huang, Bo; Ke, Degang; Xiong, Zhelun; Wang, Yu; Hu, Kanghong; Jiang, Peng; Liang, Minghui; Xiao, Zicheng; Wu, Pingfan.Covalent hybrid materials between polyoxometalates and organic molecules for enhanced electrochemical properties.Journal of Materials Science, 2020, 55(13): 5554-5570. doi.org/10.1007/s10853-020-04404-0
[78]Yao, Chenguang; Hu, Kanghong; Xi, Caili; Li, Ni; Wei, Yanhong* 2019 "Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene". Genes & Genomics, 2019, 41(3): 343-357. doi: 10.1007/s13258-018-0760-7
[77]Xiaokang Hu, Huan Wang, Bo Huang, Ni Li, Kanghong Hu*; Baolin Wu; Zicheng Xiao; Yanhong Wei; Pingfan Wu. 2019 "A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities" Journal of Inorganic Biochemistry193:130-132
[73]Yao Chenguang; Xi Caili; Hu Kanghong; Gao Wa; Cai Xiaofeng; Qin Jinlan; Lv Shiyun; Du Canghao; Wei Yanhong*. 2018 "Inhibition of enterovirus 71 replication and viral 3C protease by quercetin". Virology Journal 2018,15(1):116. doi: 10.1186/s12985-018-1023-6.
[72]Yao Chengguang, Xi Caili, Hu Kanghong et al. "Inhibition of enterovirus 71 replication and viral 3C protease by quercetin"Virology Journal 2018,15(1):116. doi: 10.1186/s12985-018-1023-6.
[71]Min Cheng; Ni Li; Nan Wang; Kanghong Hu; Zicheng Xiao; Pingfan Wu; Yanhong Wei. 2018 "Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network"Polyhedron 2018,155:313-319.
2017年
[70]HU Kanghong et al. 2017 “KNK437 Inhibits Replication and Transcription of the Hepatitis B Virus”Chinese Journal of Virology (English Version) 01:24-35
[69] Mengying Ji and Kanghong Hu*. 2017 "Recent advances in the study of hepatitis B virus covalently closed circular DNA"Virologica Sinica,2017,32(6):454-464
[68]Guoguo Ye, Ge Sun, Zhikui Cheng, Lei Zhang, Kanghong Hu et al. 2017 “p55PIK regulates alpha-fetoprotein expression through the NF-κB signaling pathway“ Life Sci. 191,104-110
[63]Cheng Z, Zhi X, Sun G, Guo W, Huang Y, Sun W, Tian X, Zhao F, Hu K*. 2016 “Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines” Journal of Medical Virology 88(4):653-663
[62]Ke Peng; Sun Honghao; Liu Mingxing; Su Zhengding; Hu Kanghong; Zhua Hongda; Guo Huilin; Sun Hongmei; Andresen Thomas Lars; Olsen Lars Folke. “Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide”IET Nanobiotechnol.2016, 10(1): 8-12
[61]Xiaoli Ye, Ming Zhou, Yonggang He, Yanmin Wan, Weiya Bai, Shuai Tao, Yanqin Ren, Xinxin Zhang, Jianqing Xu, Jing Liu, Junqi Zhang, Kanghong Hu* et al. 2016 “Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide”Scientific Reports 6:29391DOI: 10.1038/srep29391.
[56]Danzhen Pan , Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang, Chunchen Wu, Xinwen Chen, Kanghong Hu et al. 2015“Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model” PlosOne 10(5):e0125658
[55]Zhikui Cheng; Ge Sun; Wei Guo; Yayun Huang; Weihua Sun; Fei Zhao; Kanghong Hu* .2015 “Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines”.Virol Sinica .2015,30(4):261-268
[51]Zhou M, Zhao F, Li J, Cheng Z, Tian X, Zhi X, Huang Y, Hu K* .2014“Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells”J Virol Methods 195:185-193.
[50]Tian Xiaohui, Zhao Fei, Sun Weihua, Zhi Xiaoguang, Hu Kanghong * .2014 CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression.Virology Journal 11:30, doi: 10.1186/1743-422X-11-30.
[49]Ming Zhou, Yayun Huang, Zhikui Cheng, Fei Zhao, Jiafu Li, Xiaoguang Zhi,Xiaohui Tian, Weihua Sun, Kanghong Hu∗ .2014 “Revival, characterization, and hepatitis B virus infection ofcryopreserved human fetal hepatocytes”. Journal of Virological Methods, 2014, 207: 29-37.
[46]Wang W, Peng H, Li J, Zhao X, Zhao F, Hu K*. 2013“Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector.”Virus Genes 46(3):393-403
[45] Feng H, Chen P, Zhao F, Nassal M, Hu K* .2013“Evidence for multiple distinct interactions between hepatitis B virus P protein and its cognate RNA encapsidation signal during initiation of reverse transcription” PlosOne 8(8):e72798
[44] Chen P, Yun G, Li J, Zhao F, Rayner S*, Hu K*. 2013“Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival”PlosOne 8(4):e60098
[43]Pan X, Li XJ, Liu XJ, Tian XH, Hu K et al. 2013 “Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection” J Virol. 87(20):10968-10979
[41]Zhao Z, Hong W, Zeng Z, Wu Y, Hu K et al.2012 “Mucroporin-M1 inhibits hepatitis B virus replication by activating the MAPK pathway and down-regulating HNF4α in vitro and in vivo.” J Biol Chem. 287(36):30181-90
[39]Feng H , Beck J, Nassal M and Hu K*. 2011“A SELEX-Screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication”PlosOne 6(11):e27862
[38]Chen P, Rayner S, Hu K*. 2011 “Advances of bioinformatics tools applied in virus epitopes prediction”Virol Sinica. 26(1):1-7
[29]Feng H and Hu K* .2009 “Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase”. Virologica Sinica.24(6)：509-517
[20]Hu K.* and Yao Y 2008“Advances in application of three-dimensional cell culture” J Med Mol Biol 5(2):185-188
[19] 胡康洪* “乙型肝炎病毒：复制机制与基因封闭策略”中外健康文摘 临床医师 2008/08
2007年
[18]Hu K et al. 2007“Chemically defined medium determines the differential potency of renal stem cells”. Biotech J 2(8):992-995
[17]Heber S, Denk L, Hu K* et al 2007 “Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium” Tiss Engi,13(2), 281-292
[16]Will W Minuth; Lucia Denk; Kanghong Hu*. “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium” Biomaterials. 2007, (30): 4418-4428.
[15]Minuth WW, Denk L, Hu K et al. 2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor”. Central Europ J Biol,2(3), 307-325
[14]Minuth WW,Hu K*, Denk L. 2007“Kontrolliertes Environment für Stammzellen – Generierung renaler Tubuli in chemisch definiertem Kulturmedium“Bioforum 4:28-29
[13]Minuth WW, Denk L and Hu K*. 2007“Kontrolliertes Environment für die Entwicklung von Stammzellen zu renalen Tubuli” Regener Medizin 2(1):22-27
[12]Ke B. and Hu K *. 2007 "Environmental pollution and skin diseases" Medical Recapitulate 13(18), 1377-1379
[10]Nadine K., Oliver B., Ashermann K.,Hu K. et al. 2006 “Transcription of potato spindle tuber viroid by RNA polymerase II starts in the left terminal loop” Virology. 347(2), 392-404
2005年
[9]Schnabl B, Hu K. et al.2005 “Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10” Biochemi Biophys Res Communi 335, 87-96
[8]Hu K et al.2005“Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y” Biochimica et Biophysica Acta 1729:14-23
2004年
[7]Hu K. et al 2004 “SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription” Nucleic Acids Research 32(14):4377-4389
2001年
[6]Fels A,Hu K et al.2001 “Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites”Nucleic Acids Research 29(22), 4589-4597
2001年以前的
[5]Hu K. 2000 “Wechselwirkung beider Startstellen der Transkription von mutierten zirkulären Viroidmolekülen” Dissertation, Heinrich-Heine-Universität Düsseldorf, Germany 1-120 (in German)
[4]Xiong K., Jin R., Hu K. and Ding D. 1990 "Synthesis and cloning of the human growth hormone releasing factor gene"Chinese Journal of Biotechnology (English Version) 6, 243-250
3. Xiaokang Hu, Huan Wang, Bo Huang, Ni Li, Kanghong Hu* et al. 2019 “A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities” Journal of Inorganic Biochemistry 193:130-132 doi: 10.1016/J.JINORGBIO.2019.01.013
4. Yao Chengguang#, Hu Kanghong# et al. 2019 “Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene” Genes & Genomics 41(3):343-357. doi: 10.1007/s13258-018-0760-7
5. Yao Chengguang, Xi Caili, Hu Kanghong, Gao Wa, Cai Xiaofeng, Qin Jinlan, Lv Shiyun, Du Canghao, Wei Yanhong* 2018 “Inhibition of enterovirus 71 replication and viral 3C protease by quercetin” Virology Journal 15(1):116. doi: 10.1186/s12985-018-1023-6.
6. Cheng M, Li N, Wang N, Hu K, Xiao Z*, Wu P*, Wei Y* 2018 “Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network” Polyhedron 155: 313-319. doi: 10.1016/J.POLY.2018.08.052
7. Ke S *, Li N, Ke T, Shi L, Zhang Z, Fang W, Zhang Y, Wang K, Zhou R, Wan Z, Yang Z, Zhang G, Wei Y* 2018 “Synthesis and evaluation of steroidal thiazoline conjugates as potential antiviral agents” Future Medicinal Chemistry 10 (22), 2589-2605. doi: 10.4155/fmc-2018-0075
8. Ji M, Hu K*. 2017 “Recent advances in the study of hepatitis B virus covalently closed circular DNA” Virologica Sinica 32(6):454-464 doi: 10.1007/S12250-017-4009-4
9. Ye Guoguo, Sun Ge, Cheng Zhikui, Zhang Lei, Hu Kanghong, Xia Xianmin*, Zhou Yin* 2017 “p55PIK regulates alpha-fetoprotein expression through the NF-kappa B signaling pathway” Life Sciences 191:104-110 doi: 10.1016/J.LFS.2017.09.043
10. Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu et al. 2016 “Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide” IET Nanobiotechnology 10( 1): 8-12 doi: 10.1049/IET-NBT.2014.0070
11. Cheng Z, Zhi X, Sun G, Guo W, Zhao F, Hu K* 2016 “Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines” Journal of Medical Virology 2016, 88(4): 653-663. doi: 10.1002/JMV.24366
12. Ye X, Zhou M, He Y, Wan Y, Bai W, Tao S, Ren Y, Zhang X, Xu J, Liu J, Zhang J*, Hu K*, Xie Y* 2016 Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide. Scientific Reports 6: 29391. doi: 10.1038/srep29391
13. Danzhen Pan , Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang, Chunchen Wu, Xinwen Chen, Kanghong Hu et al. 2015 “Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model” PloS One 10(5):e0125658 doi: 10.1371/JOURNAL.PONE.0125658
14. Cheng Z, Sun G, Guo W, Huang Y, Sun W, Zhao F, Hu K* 2015 “Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines” Virologica Sinica 2015, 30(4): 261- 268. doi: 10.1007/S12250-015-3584-5
15. Zhou M, Huang Y, Cheng Z, Zhao F, Li J, Zhi X, Tian X, Sun W, Hu K* 2014 “Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes” Journal of Virological Methods 2014, 207: 29-37. doi: 10.1016/J.JVIROMET.2014.06.015
16. Zhou M, Zhao F, Li J, Cheng Z, Tian X, Huang Y, Zhi X and Hu K* 2014 “Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells” Journal of Virological Methods 195: 185-193. doi: 10.1016/J.JVIROMET.2013.10.010
17. Tian X, Zhao F, Sun W, Zhi X, Cheng Z, Zhou M, Hu K* 2014 “CRTC2 enhances HBV transcription and replication by inducing PGC1α expression” Virology Journal 11: 30. doi: 10.1186/1743-422X-11-30.
18. Tian X, Zhao F, Cheng Z, Zhou M, Zhi X, Li J, Hu K* 2013 “GCN5 acetyltransferase inhibits PGC1α-induced hepatitis B virus biosynthesis” Virologica Sinica 28(4):216-222. doi: 10.1007/S12250-013-3344-3
19. Chen P, Yun G, Na H, Wei F, Li J, Zhao F, Rayner S*, Hu K* 2013 “Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival” PloS One 8(4): e60098. doi: 10.1371/JOURNAL.PONE.0060098
20. Feng H, Chen P, Zhao F, Nassal M*, Hu K* 2013 “Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription” Plos One, 2013, 8: e72798. doi: 10.1371/JOURNAL.PONE.0072798
21. Pan X, Li XJ, Liu XJ, Tian XH, Hu KH. et al. 2013 “Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection” Journal of Virology 87(20):10968-10979. doi: 10.1128/JVI.01120-13
22. Wang W, Peng H, Li J, Zhao X, Zhao F, Hu K* 2013 Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector. Virus Genes 2013, 46 (3): 393-403. doi: 10.1007/S11262-013-0886-2
23. Zhao Z, Hong W, Zeng Z, Wu Y, Hu K et al. 2012 “ucroporin-M1 inhibits hepatitis B virus replication by activating the MAPK pathawy and down-regulating HNF4α in vitro and in vivo” Journal of Biological Chemistry 287(36):30181-90. doi:10.1074/jbc.M112.370312
24. Feng H , Beck J, Nassal M and Hu K* 2011 “A SELEX-Screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication” Plos One 6 (11): e27862. doi:10.1371/JOURNAL.PONE.0027862
25. Chen P , Rayner S*, and Hu K* 2011 “Advances of bioinformatics tools applied in virus epitopes prediction” Virologica Sinica 26(1):1-7 doi: 10.1007/s12250-011-3159-4
26. Hu K* 2010 “From Minu3D cultural system to aldosterone-induced tubulogenesis” Journal of Clinical Rehabilitative Tissue Engineering Research 14(2):365-369 doi:10.3969/j.issn.1673-8225.2010.02.041
27. Feng H and Hu K* 2009 “Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase” Virologica Sinica 24(6):509-517 doi: 10.1007/s12250-009-3076-6
28. Feng H and Hu K* 2008 “Aptamers against viral hepatitis from rational design to practical application” Virologica Sinica 23(5):315-320 doi:10.1007/s12250-008-2979-y
29. Minuth WW, Denk L, Hu K et al. 2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor” Central European Journal of Biology 2(3), 307-325 doi: 10.2478/S11535-007-0030-1
30. Minuth WW, Denk L and Hu K 2007 “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium” Biomaterials 28(30), 4418-4428 doi: 10.1016/J.BIOMATERIALS.2007.06.031
31. Heber S, Denk L, Hu K 2007 “Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium” Tissue Engineering 13(2), 281-292 doi:10.1089/TEN.2006.0199
32. Hu K et al. 2007 “Chemically defined medium determines the differential potency of renal stem cells” Biotechnology Journal 2(8), 992-995 doi:10.1002/BIOT.200700009
33. Hu K et al. 2005 “Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y” Biochimica Biophysica Acta 2005, 1729 (1): 14-23. doi:10.1016/J.BBAEXP.2005.03.001
34. Hu K et al. 2004 “SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription” Nucleic Acids Research 32(14): 4377-4389. doi: 10.1093/NAR/GKH772
35. Fels A, Hu K et al. 2001 “Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites” Nucleic Acids Research 29(22), 4589-4597 doi: 10.1093/NAR/29.22.4589
摘要：慢性乙型肝炎,其病原为Hepatitis B virus,简称HBV.中国作为HBV感染人数最多的国家,其中有二千多万患者被确诊为慢性肝炎(CHB),而CHB是导致肝硬化和肝癌的最主要诱因.中国科学院武汉病毒研究所研究员胡康洪带领着他的学科组,致力于慢性乙型肝炎病毒的复制机理及抗病毒治疗领域的深入研究 ……
慢性乙型肝炎，其病原为Hepatitis B virus，简称HBV。中国作为HBV感染人数最多的国家，其中二千多万确诊为慢性肝炎(CHB)，而CHB是导致肝硬化和肝癌的最主要诱因。目前，针对CHB的临床治疗主要通过注射干扰素或服用核苷(酸)类似物如拉米夫定(lamivudine)、阿地福韦(adefovir)等。然而，干扰素应答率低，副作用大；使用核苷(酸)类似物易引起耐药性病毒突变株的出现。从分子水平上理解HBV的复制机制，确立新颖的药物干预靶标,并筛选与之相应的有效抑制剂，是临床实际的迫切需要，也是胡康洪博士所领导的学科组目前的主要攻关内容。
1994年，时任研究所助理研究员的胡康洪，经教育部公开选拔，获得公派赴德国留学深造的机会。在德国，他很快凭借突出的表现获得德国弗理德里希艾伯特基金会奖学金，师从著名教授Dr. D. Riesner，在杜赛尔多夫大学物理生物研究所从事类病毒的复制机理研究。在Riesner教授的影响下渐渐对病毒RNA结构和功能领域的研究产生了极大的兴趣。于是，接下来的三年，他便一心一意在弗莱堡大学从事乙型肝炎病毒分子生物学的博士后研究。在那取得一些成果后，2003年，他转战雷根斯堡大学，作为课题组长主持领导欧盟联合项目“肝纤维化的机制研究”，对乙型肝炎病毒分子生物学和肝纤维化作了深入研究，首次鉴定核因子Y-锌指蛋白267-基质金属蛋白酶10信号途径启动肝纤维化转分化过程，为设计逆转肝纤维化和治疗肝癌提供了新的药物设计靶标。从2006年4月起胡康洪在雷根斯堡大学分子和细胞解剖学研究所担任助理教授，在承担培养大学医学博士生基础课组织学和神经解剖学的一部分教学工作之余，从事肾脏发育分子生物学和干细胞组织工程研究。他所在的研究组在世界上首创用聚脂羊毛作为“人工脉管”铺设在三维培养系统中培植肾脏干细胞，使其成功分化肾小管，为肾脏发育分子生物学基础研究和利用三维培养技术开展组织工程研究作出了重要贡献。
胡康洪，男，1964年出生，德籍华人科学家，祖籍湖北武汉，博士。现任湖北工业大学轻工学部生物工程学院二级教授，博导，德籍华人科学家，回国前是德国Regensburg大学教授。2008年全职回国，任中科院武汉病毒所国家重点实验室PI。长期从事病毒学和再生医学基础与应用研究。2013年起担任湖工大中德生物医学中心主任。迄今已发表SCI学术论文173篇，出版专著2本，已培养博士、硕士30余名。国家科学技术奖励评审专家、科技部国际重大合作项目终审专家、教育部长江学者评审专家、湖北省相关人才入选者。。
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采用HepG2.2.15细胞系和瞬时转染携带HBV全基因组的质粒的Huh7细胞系作为模型进行研究。实验结果发现：20 微摩 KNK437 对细胞没有毒性，在该浓度下KNK437 除HepG2.2.15 模型外，均下调HBV S表面抗原（HBsAg）和 e 抗原（HBeAg）向胞外分泌，抑制细胞内HBV核衣壳中 DNA 合成，降低细胞内HBV RNA 转
导语：三维细胞培养技术是指将具有三维结构不同材料的载体与各种不同种类的细胞在体外共同培养, 使细胞能够在载体的三维立体空间结构中迁移、生长, 构成三维的细胞-载体复合物。三维细胞培养技术是介于单层细胞培养与动物实验之间的一种技术，既能最大程度的模拟体内环境，又能展现细胞培养的直观性及条件可控性的优势，具有十分重要的应用价值。在生命科学领域发挥的作用日益巨大。近年来随着组织工程、生命科学和材料科学的飞速发展，人工脉管介质的第二代三维细胞培养仪已亟待在工艺上进行更新和升级，以满足临床医学和生命科学市场对细胞培养的可靠性、稳定性以及分化效率的追求。而这些，正是胡康洪教授和他的团队长期以来孜孜追求、不懈奋斗的重点目标。
